Immunomodulatory Second-Line Therapies for Immune Thrombocytopenia
نویسندگان
چکیده
منابع مشابه
Platelet desialylation correlates with efficacy of first-line therapies for immune thrombocytopenia
Immune thrombocytopenia (ITP) is a common autoimmune bleeding disorder. Despite considerable investigation, the pathogenesis of ITP remains incompletely understood, and for many patients, effective therapy is still unavailable. Using murine models and in vitro studies of human blood samples, we recently identified a novel Fc-independent platelet clearance pathway, whereby antibody-mediated desi...
متن کاملSunitinib Induced Immune Thrombocytopenia
Sunitinib is an oral tyrosine kinase inhibitor which prevents tumor growth and metastatic progression. It was approved for treatment of advanced renal cell cancer, gastrointestinal stromal tumor and advanced pancreatic neuroendocrine tumors. It has several adverse reactions on multi organ systems including hematologic system. Although the neutropenia and thrombocytopenia commonly happens as Gra...
متن کاملSunitinib Induced Immune Thrombocytopenia
Sunitinib is an oral tyrosine kinase inhibitor which prevents tumor growth and metastatic progression. It was approved for treatment of advanced renal cell cancer, gastrointestinal stromal tumor and advanced pancreatic neuroendocrine tumors. It has several adverse reactions on multi organ systems including hematologic system. Although the neutropenia and thrombocytopenia commonly happens as Gra...
متن کاملPatient-reported treatment burden of chronic immune thrombocytopenia therapies
BACKGROUND Chronic immune thrombocytopenia (ITP) is a debilitating autoimmune disorder that causes a reduction in blood platelets and increased risk of bleeding. ITP is currently managed with various pharmacologic therapies and splenectomy.This study was conducted to assess patient perceived and reported treatment side effects, as well as the perceived burden or bother, and need to reduce or st...
متن کاملSplenectomy for immune thrombocytopenia.
As with most reports of splenectomy for immune thrombocytopenia, the recent study claiming efficacy of splenectomy for human immunodeficiency virus (HIV)-related thrombocytopenia is uncontrolled, and combines responses of more and less severely thrombocytopenic patients.' In addition, important information is omitted. What were the mean platelet count increases, partial versus complete response...
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ژورنال
عنوان ژورنال: Hämostaseologie
سال: 2019
ISSN: 0720-9355,2567-5761
DOI: 10.1055/s-0039-1684032